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Since it was discovered in the 1920s, Raman spectroscopy has been used in pharmaceutical research as a non‐invasive way to provide chemical and structural information in situ, without any staining or complicated sample preparation. Nikki Withers spoke to Professor Kishan Dholakia to hear more about its use in industry and…
Scientists have discovered that liposomes can translocate through the blood brain barrier following stroke and may be able to get drugs to the lesions to stop further damage.
Dr Carsten Hopf and his team are using MALDI imaging in several applications, including drug metabolite and formulation distributions in tissues. This article investigates how this content-rich technique is enabling researchers to gain unique insights to facilitate faster and better drug discovery.
Scientists have developed microrobots that can deliver medication to specific spots inside the body while being controlled from outside the patient.
Researchers have developed a model that describes how antibody solutions separate into different phases and could be used to anticipate the stability and shelf-life of drugs.
Analytical techniques for QA/QC purposes are integral to the safe production of therapeutics. This in-depth focus looks at Raman spectroscopy for amorphous phase analysis and discusses the viable but non-culturable (VBNC) state of bacteria in environmental monitoring.
Researchers have developed a microscope that may provide insight into how safely and effectively a drug will perform in the body...
For decades, near-infrared (NIR) spectroscopy has been an invaluable tool within the laboratory and, interestingly, despite all the excellent instrumentation and technologies introduced for process control, NIR is still the most popular and mature technique available. This article will discuss the impact of NIR in pharmaceuticals from the perspective of…
Researchers have identified a method of improving the performance of infrared imaging techniques which could be useful in medical applications...
The SIFOM system uses 3D observation of cells and 3D stimulation of cells based on digital holography, and could help construct artificial neural networks...
Researchers have developed a method that can use 3D microscopy to develop ALMOST, A Label-free Multicolor Optical Surface Tomography...
Sophisticated hardware and software offer speed and precision. Pharmaceutical development often involves samples in solution or on transparent substrates. For these applications, confocal Raman imaging using an inverted beam path is an especially versatile and powerful investigative method.
90 years ago Chandrasekhara Venkata Raman and Kariamanickam Srinivasa Krishnan first documented "A New Type of Secondary Radiation," which then became known as the Raman Effect [1, 2]. Raman spectroscopy is based on this effect and is used for qualitative and quantitative analysis of the chemical components and molecules of…
Research into detecting tau proteins in the brains of Alzheimer's patients has shown that a specific tracer could detect and measure the protein levels...
Articifial intelligence has been used to administer lower doses of gadolinium, a contrast agent often left in the body after magnetic resonance imaging...
