Whitepapers/App Notes/Posters

Whitepaper: Characterising insulin as a biopharmaceutical using Analytical Ultracentrifugation

Posted: 1 September 2020 | | No comments yet

AUC was used to probe the effect of insulin concentration and the zinc chelating agent EDTA on monomer, dimer, and hexamer formation of USP Human Insulin Standard.

Today, large efforts are currently being undertaken by biopharmaceutical companies to create insulin derivatives and novel formulation to improve efficacy, administration methods, and time action profiles. In future development of insulin analogs, the effect of excipients such as zinc will need to be considered on the assembly state of the drug.

AUC as demonstrated in this application note, is shown to be useful in assessing the level of non-covalent aggregates such as the insulin hexamer.











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