Raman Spectroscopy - Articles and news items
Issue 5 2012, Supplements / 24 October 2012 / European Pharmaceutical Review
This free to view non-destructive material identification in-depth focus is supported by Horiba, B&W Tek, WITec, Kaiser Optical Systems, Cobalt Light Systems, Rigaku and DeltaNu:
- An implementation perspective on handheld Raman spectrometers for the verification of material identity
Bradley Diehl, Chi-Shi Chen, Bronwyn Grout, Jose Hernandez, Seamus O’Neill, Conor McSweeney, Jose Montenegro Alvarado and Mark Smith, Pfizer Inc
- Portable Raman spectroscopy for pharmaceutical counterfeit detection
Ravi Kalyanaraman, Michael Ribick and George Dobler, Bristol-Myers Squibb
- Ask the Expert
Webinars / 18 September 2012 / B&W Tek
** Recorded event now available on-demand **
In this free one hour instructional webinar you will learn how handheld Raman is being used to streamline the pharmaceutical manufacturing process and reduce pharmaceutical product recalls and plant shutdowns.
We provide a brief overview of typical incoming raw material inspection processes and (more…)
Featured news, News, Videos / 2 July 2012 / DeltaNu
PHARMA•ID™ is the smallest, lightest solution for cost-effective, non-destructive pharmaceutical identification. This palm-sized, easy to use Raman spectrometer identifies and validates excipients and active pharmaceutical ingredients (API) wherever testing is needed. PHARMA•ID can be used for the various phases of process analytical technology (PAT) systems and supports 21 CFR Part (more…)
Issue 2 2012 / 26 April 2012 / Clare Strachan, Senior Lecturer Pharmaceutical Sciences, School of Pharmacy, University of Otago
The use of Raman spectroscopy in pharmaceuticals has grown enormously since its appearance on the scene in the 1980s1-4. While typical Raman spectroscopy setups are able to provide chemical and physicochemical information about the sample on the bulk level, most solid samples in the pharmaceutical setting may not be assumed to be homogenous, and many critical quality attributes, such as drug release for example, depend on component distribution. Thus, obtaining chemically and spatially resolved information about pharmaceutical samples is pertinent. Since Raman microscopy imaging made its debut in the pharmaceutical setting, the range of pharmaceutical applications for which the technique has been used has continued to grow5-7.
Briefly, Raman spectroscopy involves the detection of inelastic scattering of light associated with molecular vibrations. The resulting photons have a longer (Stokes scattering) or shorter wavelength (anti-Stokes scattering) than the incident photons. In the most common setup (with spontaneous Raman scattering), the Stokes effect is detected since it is stronger. Raman spectroscopy is related to (near- and mid-) infrared spectroscopy since both techniques probe molecular vibrations, but there are several practical differences, which are due to the different molecular phenomena behind Raman scattering (polarisability change during vibration) and infrared absorption (dipole moment change, for more detail see e.g.8,9,5 for a brief explanation). While near-infrared and mid-infrared micro – scopy may also be used to gain chemically and spatially resolved information about samples, Raman microscopy has some advantages which include: (more…)
Featured news, News / 23 March 2012 / The Joint Pharmaceutical Analysis Group (JPAG)
Date: Thursday 17 May 2012
Location: The Royal Society of Chemistry, London
Organised jointly by: the Federation of Analytical Chemistry and Spectroscopy Societies (FACSS), the Joint Pharmaceutical Analysis Group (JPAG), the Royal Society of Chemistry Molecular Spectroscopy Group (MSG) and the Infrared & Raman Discussion Group (IRDG)
Featured news, News / 3 November 2011 / Renishaw
Raman spectroscopy came under the spotlight recently at the Natural History Museum in London, when Renishaw held its 2011 ‘inside Raman’ seminar in the Museum’s Flett theatre on 26th and 27th September.
Featured news, News / 27 October 2011 / Mike Claybourn, Raman Product Manager, HORIBA Scientific, 16 rue du Canal, 91160 Longjumeau France
The focus of this article is Raman spectroscopy, a technology that has a long pedigree of success in Pharmaceutical Development but has needed an evolutionary step to tech transfer effectively into Pharmaceutical Production. This change has now come through an innovative approach to whole tablet and capsule measurement called Transmission Raman Spectroscopy (TRS). There is now a flurry of activities across the industry to implement this technology into key unit processes and as a new opportunity to support a robust Real Time Release (RTR) strategy.
Issue 5 2011, Supplements / 24 October 2011 / Alain Hédoux, Klara Dégardin, Yves Roggo
Solid state transformations of APIS during manufacturing by Raman analysis of pharmaceutical molecules and dosage forms – Alain Hédoux, University Lille Nord de France; Detection, determination of chemical composition and chemical profiling of counterfeit medicines – Klara Dégardin, F. Hoffmann-La Roche & Institute of Forensic Science, University of Lausanne, Yves Roggo, F. Hoffmann-La Roche, Pierre Margot & Frederic Been, Institute of Forensic Science, University of Lausanne (more…)
Issue 3 2011 / 20 June 2011 / Lorna Ashton and Royston Goodacre, School of Chemistry, Manchester Interdisciplinary Biocentre, University of Manchester
In recent years, Raman spectroscopy has been successfully applied to bioprocessing, including industrial processes. Raman studies have typically been aimed at measuring accurately both product yields and the presence of secondary products; including glucose and ethanol levels as well as secondary metabolites present in complex non-fractionated fermentation broths1,2. However, Raman spectroscopy as a tool for monitoring the complex structural changes occurring during protein production has to date been under utilised, particularly the use of the extremely sensitive structural technique of UV resonance Raman (UVRR) spectroscopy.
The biopharmaceutical market, although currently a relatively small percentage of conventional pharmaceuticals, continues to expand with predicted revenues of over USD 100 billion for 20103-5. With continual demand for high fidelity products, from recombinant therapeutic proteins to nucleic acid-based medicinal products, the need for reliable, cost effective and appropriate analytical techniques for assessing the conformity of the products is still paramount3,5. (more…)
Issue 1 2011 / 16 February 2011 / Sulaf Assi, University of Hertfordshire, and Robert Watt & Tony Moffat, The School of Pharmacy, University of London
Raman spectroscopy offers a rapid and non-destructive technique for the identification of counterfeit medicines. Handheld Raman instruments offer the advantages of carrying the laboratory to the sample and giving a rapid pass or fail answer for the medicine inspected. It can identify a medicine regardless of its physical form as a tablet, powder, ointment, cream or liquid. However, the technique is limited as not all species of a medicine have a Raman scattering. Thus, the Raman spectrum obtained upon measuring a medicine might be due to the active pharmaceutical ingredient or any other excipient in the bulk or the coating of the formulation. (more…)
Issue 4 2010 / 19 August 2010 / Andrew Riches, Professor of Experimental Pathology, School of Medicine, University of St. Andrews and Co-authors:
C. Simon Herrington, School of Medicine
Kishan Dholakia, Elisabetta Canetta, Antonia Carruthers, Michael Mazilu, Anna Chiara de Luca, School of Physics & Astronomy
Chris Goodman, Greg Kata, Nabi Ghulam, Kadi Nourdin, Department of Urology, Ninewells Hospital & Medical School, Dundee
Raman spectroscopy has the potential to provide diagnostic information to the clinician. The technique has a number of advantages allowing individual cells to be interrogated without staining. With further developments in technology, the surgeon will be able to rapidly acquire accurate diagnostic information at the time of operation using fibre optic Raman probes. Improvements in signal detection and data analysis, like modulated Raman spectroscopy, will allow the rapid acquisition and analysis of spectra. There is also considerable potential in screening tissue fluids for cancer cells in order to facilitate early detection and for follow up after surgery for cancer. Collaborations between clinicians, pathologists and physicists are opening up new areas in this rapidly developing field. (more…)
Issue 4 2010 / 19 August 2010 / Professor Alastair J. Florence, Solid-State Research Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde
The majority of active pharmaceutical ingredients (APIs) are produced by crystallisation and so the phenomenon of polymorphism, whereby an organic molecule can adopt more than one crystalline form (Figure 1 ), is of considerable importance when trying to achieve consistent product quality during the manufacture of pharmaceutical solids and solid dosage forms. Although morphology and particle size-distribution are important solid-state characteristics, the uncontrolled occurrence of multiple physical forms (polymorphs, solvates, salts, co-crystals or amorphous) of an API can have significant effects on the performance of the material during processing, manufacture, storage and administration. For example, the solubility difference between some polymorphs has been shown to be over four times that of the least soluble form1 and can vary by significantly more for amorphous forms2. (more…)