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Close up of blue and white tablets spilling out of a medicine bottle onto a table with blurred background - idea of solid form narrow therapeutic index drugs
Close up of blue and white tablets spilling out of a medicine bottle onto a table with blurred background - idea of solid form narrow therapeutic index drugs
article

Physicochemical failure modes for first-line therapy Narrow Therapeutic Index (NTI) drugs: a call for attention NTI risk classification and New Prior Knowledge

2 July 2021 | By , , ,

In this article, Dr Harsh Shah and colleagues summarise their research into the importance of characterising physicochemical characteristics that can result in stress-induced solid-state changes in Narrow Therapeutic Index (NTI) drugs.

person's hands moving wooden blocks labelled with the letters mRNA and a picture of a syringe - idea of mRNA-based vaccines
person's hands moving wooden blocks labelled with the letters mRNA and a picture of a syringe - idea of mRNA-based vaccines
article

What are the challenges in developing and delivering lipid nanoparticle mRNA-based vaccines?

29 June 2021 | By ,

In response to the COVID-19 pandemic caused by the SARS-CoV-2 virus, the emergence of RNA vaccine technology has enabled rapid development of critical vaccines. Traditional vaccine production methods makerapid development challenging, requiring cell line production of viral proteins and laborious purification development, which requires extensive effort and long timelines. RNA…

cloured molecular structures of antibodies - a type of protein that undergoes O-glycosylation
cloured molecular structures of antibodies - a type of protein that undergoes O-glycosylation
article

O-glycan analysis of therapeutic proteins enabled by O-glycoprotease

29 June 2021 | By , ,

Glycosylation of therapeutic proteins is important to biologic drug development and is a critical quality attribute that is monitored during manufacturing. Analysis of O-glycans is technically challenging compared to that of N-glycans. In this review, Xiaofeng Shi, Saulius Vainauskas and Christopher H Taron summarise current O-glycan analytical approaches, describe the…

Antibody
Antibody
article

VIRTUAL ROUNDTABLE HIGHLIGHTS: Emerging tools for the analysis of biologics and biosimilars

28 June 2021 | By

In this virtual roundtable, Scott Bradley (Principal Research Scientist, Eli Lilly and Company), Joan Malmstrøm (Principal Scientist, Novo Nordisk) and Kelly Sackett (Principal Scientist, Pfizer) exemplified how high-resolution nuclear magnetic resonance (NMR) is a key technology that provides critical information about protein structure and dynamics. Here, the participants offer some…