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Chronic lymphocytic leukaemia (CLL)

AstraZeneca BTK inhibitor tablet approved in EU for leukaemia

22 February 2023 | By Catherine Eckford (European Pharmaceutical Review)

The tablet formulation for AstraZeneca’s BTK inhibitor has gained EU approval for co-administration with gastric acid-reducing agents in chronic lymphocytic leukaemia patients.

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MHRA authorises BRUKINSA^® in Great Britain for two cancers

20 January 2023 | By Catherine Eckford (European Pharmaceutical Review)

BRUKINSA® (zanubrutinib) has been authorised by the MHRA for chronic lymphocytic leukaemia and marginal zone lymphoma in Great Britain.

3d illustration of T cells attacking cancer cells - idea of T-cell therapy

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Advancing cell therapies – γδ T cells and the combination factor

13 July 2022 | By Hannah Balfour (European Pharmaceutical Review)

In this Q&A, Bryan Kobel, Chief Executive Officer of TC Biopharm, discusses innovations in cell therapies, introducing the company’s work in gamma delta (γδ) T-cell technologies and his predictions for the future of cell therapy development.

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Pharmacovigilance Risk Assessment Committee (PRAC) meeting highlights, Oct 2021

1 November 2021 | By Anna Begley (European Pharmaceutical Review)

EMA's drug safety committee (PRAC) assessed risks with COVID-19 vaccines and identified no risk of death with Imbruvica and ACE inhibitors.

Man in white coat (oncologist) holding hand of female cancer patient in a hospital bed

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Chemotherapy-free combination shows potential in lymphocytic leukaemia trial

8 June 2021 | By Hannah Balfour (European Pharmaceutical Review)

Imbruvica® (ibrutinib) plus Venclexta®/Venclyxto® (venetoclax) resulted in 95 percent of chronic lymphocytic leukaemia patients surviving without disease progression for two years.

Blood smear under microscopy showing chronic lymphoblastic leukemia (CLL)

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Imbruvica^®-based regimens induce lasting remissions in leukaemia trials

20 May 2021 | By Hannah Balfour (European Pharmaceutical Review)

Imbruvica® (ibrutinib) plus ventoclax and single-agent Imbruvica induced remissions lasting up to seven years in first-line treatment of chronic lymphocytic leukaemia.

sign of the European Medicines Agency building in Amsterdam [Credit: martinbertrand.fr/Shutterstock.com].

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European Medicines Agency’s CHMP meeting highlights March 2021

29 March 2021 | By Hannah Balfour (European Pharmaceutical Review)

In its March meeting the EMA’s human medicines committee recommended five medicines for approval and concluded its review of regdanvimab as a treatment for COVID-19.

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New oral chronic lymphocytic leukaemia treatment made available on NHS

19 March 2021 | By Hannah Balfour (European Pharmaceutical Review)

AstraZeneca’s Calquence (acalabrutinib), a chemotherapy-free monotherapy, will be offered to patients with chronic lymphocytic leukaemia.

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NICE recommends new chemo-free chronic lymphocytic leukaemia treatment

13 November 2020 | By Hannah Balfour (European Pharmaceutical Review)

More than 1,000 people each year could benefit from treatment with a combination of venetoclax and obinutuzumab, according to NICE.

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FDA approves IMBRUVICA^® (ibrutinib) for treatment of chronic lymphocytic leukaemia and small lymphocytic lymphoma

22 April 2020 | By Victoria Rees (European Pharmaceutical Review)

IMBRUVICA (ibrutinib), in combination with rituximab, has been given approval in the US for the treatment of chronic lymphocytic leukaemia and small lymphocytic lymphoma.

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EC approves KTE-X19 for treatment of mantle cell lymphoma

30 January 2020 | By Joe Doherty (European Pharmaceutical Review)

KTE-X19, an investigational CAR T-cell therapy, has been granted marketing authorisation by the European Commission.

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Imbruvica^® granted expanded use from European Commission

14 August 2019 | By Victoria Rees (European Pharmaceutical Review)

The European Commission has approved the drug for two indications: chronic lymphocytic leukaemia and Waldenström's macroglobulinemia.

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NICE recommends access to venclyxto for adult leukaemia

6 October 2017 | By Dr Zara Kassam (European Pharmaceutical Review)

NICE has issued a final appraisal determination recommending that venclyxto is made available to patients with chronic lymphocytic leukaemia...

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SMC recommends three new medicines for routine use

11 August 2017 | By Dr Zara Kassam (European Pharmaceutical Review)

The Scottish Medicines Consortium has published advice accepting three new medicines for routine use...

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Blood cancer study yields disappointing results

19 July 2016 | By Niamh Louise Marriott

Gazyvaro did not meet its primary endpoint of significantly reducing the risk of disease worsening or death in people with diffuse large B-cell lymphoma...

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Chronic lymphocytic leukaemia (CLL)