Preclinical Research

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Advances in automated performance verification for UV/VIS spectrophotometers

22 August 2018 | By Mettler-Toledo

Regulated environments require performance verification (qualification) of UV/VIS spectrophotometers on a regular basis. Instrument performance is the main factor directly affecting the accuracy and repeatability of measurements. Hence, it is important that this is regularly monitored and that documentary evidence is provided. Optical performance verification is conducted to the widely…

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Whitepaper: Why should you care about Burkholderia cepacia?

17 August 2018 | By Charles River

The Burkholderia cepacia complex (BCC) species are a group of gram-negative, rod-shaped bacteria that have been shown in recent years to be of concern for patients, and thus for manufacturers of drugs and products that contribute to patient health...

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Anticancer drug nintedanib found to be effective against malignant pleural mesothelioma

18 May 2018 | By European Pharmaceutical Review

Researchers have found that nintedanib shows promising effectiveness in halting the growth of human malignant pleural mesothelioma in preclinical models.

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Robotic method isolates high-producing cell lines for HIV vaccine production

6 February 2018 | By Dr Zara Kassam (European Pharmaceutical Review)

Technical advances in vaccine production should shorten the time to clinical trials, breaking the logjam of promising new candidate vaccines waiting to be tested...

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Scientists identify bacterial link with oesophageal cancer

1 December 2017 | By European Pharmaceutical Review

Researchers at NYU Langone Health's Perlmutter Cancer Center report that at least three kinds of bacteria in the mouths of Americans may directly affect their risk of developing oesophageal cancer.

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Drugs taken before surgery may reduce metastatic recurrence

7 August 2017 | By Dr Zara Kassam (European Pharmaceutical Review)

Researchers have identified a drug regimen administered prior to and after surgery that significantly reduces the risk of post-surgical cancer recurrence...

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Collaboration is ‘game changer’ in delivering cell and gene therapies

19 June 2017 | By Niamh Marriott (European Pharmaceutical Review)

Collaboration between the pharmaceutical industry, patients and health regulators will be a ‘game changer’ in delivering exciting new cell and gene therapies to treat conditions like cancer and vision loss.

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Ensuring patient safety during clinical trials; translation to preclinical drug discovery

3 September 2012 | By David Cook & James Milligan, AstraZeneca

Ensuring patient safety during clinical trials is of paramount consideration with stringent monitoring built into trials (and beyond) and the design and interpretation of safety outcomes subject to a large amount of regulation. As a result, it is rare for clinical trials to produce extreme adverse drug reactions but it…

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MRI in drug discovery

28 February 2012 | By Peter R. Allegrini, Novartis Institutes for BioMedical Research

MRI is widely used for clinical diagnosis as well as in research areas such as preclinical drug discovery, clinical development and also in therapy monitoring. MRI allows non-invasive acquisition of tomographic images of soft tissue with high resolution and contrast. Furthermore, its ability to assess organ function in a broad…