Whitepaper/App Note

Whitepaper: Raman-Based Nutrient Control in Bioprocessing Optimises Viable Cell Density and Protein Glycation

Posted: 1 September 2017 | | No comments yet

Production of protein therapeutics by mammalian cells is the most widely used bioprocess because of its ability to properly produce and fold a recombinant protein…

60-70% of biopharmaceuticals are produced by this bioprocess. Bioreactor parameters affect cell metabolic processes and detailed bioreactor knowledge is needed to achieve a balanced and consistent metabolic state of cultured cells.

An online Raman-driven feedback control system was shown to improve a biopharmaceutical protein product’s quality. Raman can simultaneously measure other bioreactor parameters in addition to glucose, including lactate, osmolality and cell density, providing a detailed profile of bioreactor parameters.

 

This whitepaper is restricted - login or subscribe free to access

Issue 6 2018 magazine coverThank you for visiting our website. To access this content in full you'll need to login. It's completely free to subscribe, and in less than a minute you can continue reading. If you've already subscribed, great - just login.

Why subscribe? Join our growing community of thousands of industry professionals and gain access to:

  • bi-monthly issues in print and/or digital format
  • case studies, whitepapers, webinars and industry-leading content
  • breaking news and features
  • our extensive online archive of thousands of articles and years of past issues
  • ...And it's all free!

Click here to Subscribe today Login here

 

Send this to a friend