Whitepaper/App Note

Whitepaper: Raman-Based Nutrient Control in Bioprocessing Optimises Viable Cell Density and Protein Glycation

Posted: 1 September 2017 | | No comments yet

Production of protein therapeutics by mammalian cells is the most widely used bioprocess because of its ability to properly produce and fold a recombinant protein…

60-70% of biopharmaceuticals are produced by this bioprocess. Bioreactor parameters affect cell metabolic processes and detailed bioreactor knowledge is needed to achieve a balanced and consistent metabolic state of cultured cells.

An online Raman-driven feedback control system was shown to improve a biopharmaceutical protein product’s quality. Raman can simultaneously measure other bioreactor parameters in addition to glucose, including lactate, osmolality and cell density, providing a detailed profile of bioreactor parameters.

 

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