Whitepapers/App Notes/Posters

Application Note: Representative sampling of solids and turbid media in process raman spectroscopy

Posted: 12 December 2018 | | No comments yet

Raman spectroscopy is an analysis technique that provides a “molecular fingerprint” of the sample, enabling analysis of chemical composition and molecular structure without sample preparation. As a measurement technique, Raman imparts many benefits in applications from laboratory discoveries to feedback-control in manufacturing.

Key Issues

  • Understanding the effect of optical scattering on collection of Raman signal in solids and turbid media
  • Large volumetric Raman probes harnesses optical scattering to get representative sampling in solids
  • Backscattered Raman probes reduces optical scattering for robust in situ bioprocess monitoring and control


In situ real-time analysis, compatibility with aqueous systems, non destructive nature, and high chemical specificity means that the Raman-analyzed sample is representative of the process. Because Raman is a non-destructive technique, the same sample measured by Raman can also be measured by other analytical techniques. These well-known features have been harnessed throughout the pharmaceutical industry for small molecule pharmaceutical manufacturing and bioprocessing.

The rest of this application note is restricted - login or subscribe free to access

Thank you for visiting our website. To access this content in full you'll need to login. It's completely free to subscribe, and in less than a minute you can continue reading. If you've already subscribed, great - just login.

Why subscribe? Join our growing community of thousands of industry professionals and gain access to:

  • bi-monthly issues in print and/or digital format
  • case studies, whitepapers, webinars and industry-leading content
  • breaking news and features
  • our extensive online archive of thousands of articles and years of past issues
  • ...And it's all free!

Click here to Subscribe today Login here