• Facebook
  • Twitter
  • LinkedIn
  • Google +
  • RSS

Biomarkers - Articles and news items

BMS Phase II study in non-alcoholic steatohepatitis a success 

Industry news / 24 April 2017 / Niamh Marriott, Junior Editor

BMS-986036 is a pegylated analogue of human fibroblast growth factor 21, a key regulator of metabolism. In preclinical models of non-alcoholic steatohepatitis (NASH), BMS-986036 improved steatosis, inflammation, hepatocyte ballooning, and fibrosis. In a Phase 2 study in obese patients with type 2 diabetes, it improved insulin sensitivity, lipids, adiponectin, and fibrosis biomarkers. This Phase 2 […]

GeNeuro initiates Phase 2a study in Australia to treat Type 1 Diabetes

Industry news / 19 April 2017 / Niamh Marriott, Junior Editor

GeNeuro have started a Phase 2a clinical study in Australia with GNbAC1 in patients with Type 1 diabetes. GNbAC1 is a monoclonal antibody designed to…

Biocartis and Merck partnership launch second liquid biopsy assay

Industry news / 15 March 2017 / Niamh Marriott, Junior Editor

This collaboration is aimed at jointly developing and commercialising new liquid biopsy RAS biomarker tests for metastatic colorectal cancer (mCRC)…

Dolomite Bio’s Single Cell RNA-Seq System accelerating cancer research

Dolomite Bio’s Single Cell RNA-Seq System accelerating cancer research

Supplier news / 8 December 2016 / Dolomite Bio

Researchers at The Institute of Cancer Research (ICR), London, are taking advantage of the single cell encapsulation capabilities of Dolomite Bio’s Single Cell RNA-Seq System to investigate resistance mechanisms in prostate cancer…

FDA approves Roche’s immunotherapy assay to support treatment decisions in lung cancer

Industry news / 31 October 2016 / Niamh Louise Marriott, Digital Content Producer

The US Food and Drug Administration (FDA) has approved Roche’s PD-L1 assay as a diagnostic to identify PD-L1 expression levels in patients considering treatment with Tecentriq (atezolizumab) for previously treated metastatic non-small cell lung cancer (NSCLC). The PD-L1 (SP142) assay is also indicated to identify patients with urothelial cancer (UC) who may benefit from treatment […]

Biomarker breakthrough could improve Parkinson’s treatment

Industry news / 16 August 2016 / University of Florida

Scientists have found that using magnetic resonance imaging reveals areas where Parkinson’s disease causes progressive decline in brain activity, a biomarker discovery which will help to evaluate new experimental treatments to slow or stop the disease’s progression…

First patient enrolled in IPF biomarker study of Ofev

Industry news / 30 June 2016 / Victoria White, Digital Content Producer

INMARK is a study investigating the effect of Ofev (nintedanib) on changes in specific blood biomarkers in patients with idiopathic pulmonary fibrosis…

MIQE compliance in expression profiling and clinical biomarker discovery

MIQE compliance in expression profiling and clinical biomarker discovery

Cancer Biology, Issue 6 2015 / 6 January 2016 / Irmgard Riedmaier, Melanie Spornraft, Benedikt Kirchner and Michael W. Pfaffl, Technical University of Munich

Molecular diagnostics and biomarker discovery are gaining increasing attraction in clinical research. This includes all fields of diagnostics, such as risk assessment, disease prognosis, treatment prediction and drug application success control. The detection of molecular clinical biomarkers is very widespread and can be developed on various molecular levels, like the genome, the epi-genome, the transcriptome, the proteome or the metabolome. Today, numerous high-throughput laboratory methods allow rapid and holistic screening for such marker candidates. Regardless of which molecular level is analysed, in order to detect biomarker candidates, high sample quality and a standardised and highly reproducible quantification workflow are prerequisites. This article describes an optimal and approved development strategy to discover and validate ‘transcriptional biomarkers’ in clinical diagnostics, which are in compliance with the recently developed MIQE guidelines. We focus on the importance of sample quality, RNA integrity, available screening and quantification methods, and biostatistical tools for data interpretation…

AYOXXA & SERI to collaborate on protein biomarker detection

AYOXXA and SERI to collaborate on protein biomarker detection

Industry news / 3 February 2015 / AYOXXA Biosystems / SERI

AYOXXA and SERI will work together on validating the company’s multiplexing technology platform for protein biomarker detection, as part of an expanded collaboration for developing ophthalmic diagnostic tools…

Your next clinical biomarker will be assayed by mass spectrometry....or not!

Your next clinical biomarker will be assayed by mass spectrometry….or not!

Issue 6 2014 / 23 December 2014 / Axel Ducret, Biochemist

This article will focus on some of the critical aspects of transition biomarkers discovered in classical (MS-based) proteomics workflows and on the challenges to be met before validated assays can become more routine in the clinical laboratory…

SLAS2015 : Promises Information, Innovation and Connections

Issue 6 2014 / 23 December 2014 / The Society for Laboratory Automation & Screening (SLAS)

The Society for Laboratory Automation and Screening (SLAS) is proud to present SLAS2015, the Fourth Annual Conference and Exhibition of the Society…

Amancio Carnero, Instituto de Biomedicina de Sevilla, Consejo Superior de Investigaciones Científicas

Biomarkers for cancer treatment

Cancer Biology, Issue 5 2013 / 22 October 2013 / Amancio Carnero, Instituto de Biomedicina de Sevilla, Consejo Superior de Investigaciones Científicas

There is an urgent need to predict which treatment will report the most benefit to a patient with cancer. To that end, scientists are exploring any possible biomolecule in the organism that can mark each individual for its adequate treatment. If achieved, it will open a personalised medicine era.