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Scientific poster: Chromatography essentials for performing perfect separations
This free poster compiles all basic chromatography principles needed to develop and run flash and prep HPLC methods.
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Chromatography
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Analytical methods used in obtaining higher order structure information from protein therapeutics
The efficacy, safety and pharmacokinetic properties of a protein therapeutic substantially depend on the molecule having the right structure. This article reviews current methods used for obtaining higher order structure information of biotherapeutics.
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Expert View: Eshmuno® CP-FT resin – developed for the flow-through removal of aggregates using frontal chromatography
Eshmuno® CP-FT cation exchange resin is specifically designed to provide efficient removal of monoclonal antibody (mAb) aggregates in the flow-through frontal chromatography mode of operation enabling loading capacities 10-times higher than traditional bind/elute CEX chromatography. It facilitates greater manufacturing flexibility and process intensification while reducing the overall cost for the…
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Scientific poster: High-throughput proteome analysis using 50 cm micro pillar array columns (μPAC™)
The practice of bottom-up proteomics relies to a large extent on the separation performance that can be achieved with state-of-the art nano LC-MS/MS equipment.
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Scientific poster: Nuvia aPrime 4A: a hydrophobic anion exchange resin for refined selectivity and recovery
The elimination of product and process related impurities is essential to the safety and efficacy of biopharmaceuticals.
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Whitepaper: Ultrapure water for HPLC analysis
This whitepaper demonstrates the High Performance Liquid Chromatography (HPLC) separation and analysis technique and highlights the importance of using water of sufficient purity as an eluent and how the arium® pro VF system can facilitate this.
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Booklet: How to reduce hazards in the chromatography lab
As maintaining the health of the chemist is of top priority, one should recognise potential dangers that can jeopardise the safety of laboratory staff and install measures to sufficiently protect the scientists.
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Project launched to tackle lab inefficiency, support AI adoption
A project backed by major pharma will advance the Lab of the Future with proof of concept software to digitise experiment methods…
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PharmaFluidics’ new product launch steers ‘on-a-chip’ separations of complex biological samples to new heights
PharmaFluidics NV is a game-changing innovator in the field of analytical chromatography. The company has devised a fundamentally new way of performing separations by creating nano-LC columns on a silicon chip...
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LC-MS based multi-attribute method for characterisation and QC testing of protein therapeutics
For several decades mass spectrometry (MS) has been used in the characterisation of protein pharmaceuticals.1-3 However, its use in the laboratory for quality control (QC) product release testing has been quite limited for a number of reasons, for example: instrument complexity and software are not readily amenable to validation, extensive…
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Scientific Poster: Quantitation of monoclonal antibody infliximab in human plasma by LC-MS/MS using Fab-selective limited proteolysis nSMOL technology
Infliximab, commercially known as Remicade, is a chimeric IgG1 kappa monoclonal antibody (mAb), that targets tumor necrosis factor-alpha (TNF)....
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Separations & Purifications In-Depth Focus 2018
In this issue: the role of bioptherapeutics in curing a range of diseases, and is supercritical fluid chromatography applicable to achiral separations?
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Advanced autosampler and liquid handling system improves lab productivity
Multi-step, automated workflows designed to be versatile, fast and offer high throughput...
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Waters Corporation to invest $215 million in precision chemistry manufacturing in Massachusetts
New state-of-the-art facility will support continued growth and innovation...
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New software toolset advances small molecule analysis
Easy-to-use software helps identify unknown compounds and extracts high-confidence understanding from complex mass spectra...
