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There has been a lot of interest in enhancing the sensitivity of Raman spectroscopy due to the low efficiency of the Raman technique. A pre-concentration technique, drop-coating deposition Raman (DCDR), has been used in recent years to increase the utility of Raman spectroscopy by decreasing the detection limit for non-enhanced…
90 years ago Chandrasekhara Venkata Raman and Kariamanickam Srinivasa Krishnan first documented "A New Type of Secondary Radiation," which then became known as the Raman Effect [1, 2]. Raman spectroscopy is based on this effect and is used for qualitative and quantitative analysis of the chemical components and molecules of…
The use of micro pillar array columns (μPAC™) for characterising antibody-drug conjugates is presented. Kadcyla® (ado-trastuzumab emtansine) and, for comparison, Herceptin® (trastuzumab) tryptic digests were analysed on a 200 cm μPAC™ C18 column and peaks eluting were detected by ultraviolet (UV) spectroscopy and high-resolution mass spectrometry (MS).
Raman spectroscopy is an analysis technique that provides a “molecular fingerprint” of the sample, enabling analysis of chemical composition and molecular structure without sample preparation. As a measurement technique, Raman imparts many benefits in applications from laboratory discoveries to feedback-control in manufacturing.
BrightSpec is first to commercialise molecular rotational resonance (MRR) spectroscopy for drug discovery and process R&D applications.
For several decades mass spectrometry (MS) has been used in the characterisation of protein pharmaceuticals.1-3 However, its use in the laboratory for quality control (QC) product release testing has been quite limited for a number of reasons, for example: instrument complexity and software are not readily amenable to validation, extensive…
Researchers from the University of Tokyo have developed a method to use machine learning to interpret data from spectroscopy techniques...
Modern laboratories use a number of gases as part of their daily operations. This application note details two of the most common methods of laboratory gas supply, and their associated safety risks and benefits...
22 August 2018 | By Mettler-Toledo
Regulated environments require performance verification (qualification) of UV/VIS spectrophotometers on a regular basis. Instrument performance is the main factor directly affecting the accuracy and repeatability of measurements. Hence, it is important that this is regularly monitored and that documentary evidence is provided. Optical performance verification is conducted to the widely…
Metrohm AG from Herisau, Switzerland and B&W Tek from Newark in Delaware, USA are pleased to announce the acquisition of B&W Tek’s Spectroscopy Solution Business, B&W Tek LLC, as well as several overseas subsidiaries. This acquisition contributes to the strategic growth of Metrohm enhancing the company’s capabilities to further develop…
ProCellics™, first in-line and real-time bioprocess raman analyser, is a RESOLUTION Spectra Systems product. It offers a GMP user-friendly and easily deployed Process Analytical Technology (PAT) solution...
In this issue: the applications of vibrational spectroscopy for analysing the molecular component of a solid sample, and Raman as a fast-growing tool for PAT/QbD
Bruker today announces the launch of the new INVENIO™ Fourier Transform Infrared (FT-IR) research spectrometer. The INVENIO is the successor to the renowned VERTEX 70 FT-IR for advanced R&D applications...
When irradiated, less stiff extracellular matrices reduced cancer growth and migration, bolstering the case to further understand fractionated radiation therapy...
