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Non-clinical dose formulation considerations

15 December 2017 | By

Designing appropriate non-clinical safety studies requires thoughtful, and sometimes experimental, consideration of the delivery methodology for the therapeutic. The choice of formulation affects drug release and absorption and has a direct impact on the pharmacokinetic profile and associated response of the model system. The formulation should be compatible with the…

Improving patient access, the UCB way

23 November 2017 | By

UCB’s ambition, according to its website, is to transform the lives of people living with severe diseases. The company’s Head of Global Clinical Development and Medical Affairs Stuart Dollow believes that making its clinical trial design more patient-centred and creating the right partnerships are key steps toward improving access to…

Regulatory, clinical and logistics challenges of Advanced Therapy Medicinal Products (ATMPs) in clinical research

8 November 2017 | By ,

Advanced Therapy Medicinal Products (ATMPs) are new therapeutics that require different procedures for clinical trials compared to traditional medicinal products. It is important to understand the nature and the manufacturing process of an ATMP for set-up and execution of the clinical development and later marketing of these therapies.

The importance and efficacy of epigallocatechin and epicatechin

25 October 2017 | By , , ,

Plant extracts have been used in African folk medicine to treat a wide array of infections, especially in Nigeria, for centuries. This article considers the potential medicinal uses and efficacy of the flavonoids epigallocatechin and epicatechin, which can be extracted from the Spondias mombin plant.