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The United States Pharmacopoeia (USP)

 

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O-glycan analysis of therapeutic proteins enabled by O-glycoprotease

29 June 2021 | By , ,

Glycosylation of therapeutic proteins is important to biologic drug development and is a critical quality attribute that is monitored during manufacturing. Analysis of O-glycans is technically challenging compared to that of N-glycans. In this review, Xiaofeng Shi, Saulius Vainauskas and Christopher H Taron summarise current O-glycan analytical approaches, describe the…