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Scientific poster: Common Laboratory Techniques in the Drug Discovery Workflow
The characterization of novel therapeutics involves many chemical processes.
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Therapeutics
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Can calorimetry provide accurate estimates of long‑term stability for monoclonal antibodies?
Differential scanning calorimetry (DSC) has been one of the most widely used techniques to characterise the temperature stability of monoclonal antibodies (mAbs) and provide important information in formulation optimisation. However, despite its widespread use, not all the information contained in DSC data, especially denaturation kinetics, is routinely extracted. In this…
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Single-use strategies for downstream processing
All therapeutic developers and manufacturers are under intense pressure to improve efficiency and productivity and reduce costs, all while maintaining the highest quality standards.
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Application note: Cell-Based Therapies – Be on the Safe Side
Get QC Results for Advanced Therapy Medicinal Products (ATMPs) Before Treatment.
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British Columbia first province to switch patients to biosimilars
British Columbia has said it will switch as many as 20,400 patients from three branded biologic drugs to cheap biosimilars.
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Drug combination may become new standard treatment for advanced kidney cancer
Immunotherapy drug plus targeted agent provided better progression-free survival and shrank tumors in more patients than standard one-drug treatment...
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Pricing dispute over cystic fibrosis drug Orkambi continues in the UK
Campaigners call for UK Government to intervene on pricing dispute over cystic fibrosis drug Orkambi...
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Developing the production of the radioisotope Tc-99m within the US
A team of university researchers have collaborated together to develop a method to produce the radioisotope Tc-99m in the US to prevent having to import it...
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Application Note: Quantitation of intact therapeutic protein in plasma matrix by LC/MS
A complete workflow to quantify intact therapeutic proteins in plasma matrix has been developed, covering three critical components in preclinical sample analysis: target protein enrichment/purification, LC/MS data acquisition and quantitative data analysis.
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Whitepaper: Characterising antibody-drug conjugates using micro pillar array columns combined with mass spectrometry (μPAC™-MS)
The use of micro pillar array columns (μPAC™) for characterising antibody-drug conjugates is presented. Kadcyla® (ado-trastuzumab emtansine) and, for comparison, Herceptin® (trastuzumab) tryptic digests were analysed on a 200 cm μPAC™ C18 column and peaks eluting were detected by ultraviolet (UV) spectroscopy and high-resolution mass spectrometry (MS).
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Drug delivery to the brain using scorpion venom
IRB researchers have developed a method to use a peptide found in chlorotoxin identified in scorpion venom to deliver drugs through the blood-brain barrier...
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Immunotherapy success for triple-negative breast cancer
A combination of chemotherapy and immunotherapy could soon be used in NHS hospitals for triple-negative breast cancer to extend patient survival...
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NIAID plan for in-depth tuberculosis research
NIAID has released a plan for research in the infectious disease TB in order to strengthen efforts and resolve to attack this disease...
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Pioneering radiotherapy machine treats its first patient in the UK
Improved accuracy and fewer patient side effects are among the benefits claimed for the pioneering radiotherapy machine...
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Is cancer fundraising fuelling deceit?
Researchers questioned whether cancer crowdfunding elicits deception, especially when offering patients treatments with no scientific backing...
