Johns Hopkins University - Articles and news items

Cancer immunotherapy drugs linked to autoimmune diseases

Industry news / 24 June 2016 / Victoria White, Digital Content Producer

Some cancer patients taking the immunotherapy drugs ipilimumab and nivolumab may be at a higher-than-normal risk of developing autoimmune diseases…

ITC: affinity is not everything

Issue 1 2009, Past issues / 7 February 2009 /

During the optimisation of drug candidates, improvements in affinity and selectivity play a critical role. This task is usually accomplished by establishing accurate correlations between the affinity/selectivity of different chemical scaffolds and through chemical modifications to a selected scaffold.

A new era for microcalorimetry in drug development

Issue 5 2007, Past issues / 21 September 2007 / Dr Ernesto Freire, Faculty Professor, Johns Hopkins University, Baltimore

Drug development involves the identification and subsequent optimisation of low molecular weight compounds with a desired biological activity. Often, the initial binding affinity of those compounds towards their intended target needs to be improved by five or more orders of magnitude before they become viable drug candidates; a process that would be greatly facilitated if the different forces that contribute to binding were experimentally accessible. Isothermal titration calorimetry (ITC) provides such a tool.


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