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Pharma Horizons: leading-edge formulation
This report addresses the key factors shaping pharmaceutical formulation, including regulation, QC and analysis.
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Articles
Biotechnica 2009 – Europe’s leading gathering for the biotech industry
9 October 2009 | By
For three days the halls will be alive with exhibitors and visiting professionals from all over the world, together with distinguished speakers and investors - all to discuss the latest products, innovations, research findings and market opportunities.
Raman spectroscopy in pharmaceutical analysis
9 October 2009 | By
A wide and versatile range of analytical techniques are routinely used, indeed are necessary, in pharmaceutical analysis. Over the past decade Raman spectroscopy has increasingly come to the fore as a valuable member of the arsenal of methods used, from both a fundamental and applied perspective, for the interrogation of…
Sleep changes as translational pharmacodynamic biomarkers
9 October 2009 | By
Pharmacodynamic biomarkers in drug discovery: Developing a new drug is an expensive and time-consuming business1-3. A substantial part of the overall cost of drug development is the investment in molecules that fails at some point during the development process and it is necessary to identify these compounds as early as possible.…
ELRIG.de Forum 2009 – Innovation Welcome
9 October 2009 | By
The ELRIG Forum 2009 is organised in cooperation with the European ScreeningPort and the North German life science agency Norgenta.
Article 5: qPCR data analysis – Amplification plots, Cq and normalisation
9 October 2009 | By
A pivotal attraction of qPCR technology is its apparent lack of complication; an assay consisting of the simple procedure of combining oligonucleotides, PCR mastermix buffer and nucleic acid template to produce a qPCR reaction is perceived as undemanding. This practical simplicity is complemented by the absence of any requirement for…
Real-time NIR monitoring of pharmaceutical blending processes with multivariate quantitative models
9 October 2009 | By Dr. Nicolas Abatzoglou, Professor and Chairman of the Department of Chemical & Biotechnological Engineering of the Université de Sherbrooke; Pierre-Philippe Lapointe-Garant, PAT Scientist and Jean-Sébastien Simard, Technical Services, both Wyeth Pharmaceuticals
Process analytical technology (PAT) initiatives are now an integral part of developmental efforts in the pharmaceutical industry. Many technical and scientific papers and even dedicated sections appear regularly in several pharmaceutical manufacturing publications. They may be part of a quality by design (QbD) project to better identify and understand critical…
MipTec 2009 – The Leading European Event for Drug Discovery
9 October 2009 | By
The conference in October 2008 marked some dramatic changes for MipTec: Most notable was the policy of free registration for the conference and exhibits. This drew a record attendance for the 12 years of the conference with more than 2,300 attendees. It was so successful that free registration will be…
RNAi applications in biology and medicine
30 July 2009 | By
The field of oligonucleotide-based therapy experienced a revival with the discovery of RNA interference (RNAi) in 19981. RNAi is a conserved endogenous mechanism, which is triggered by double-stranded (ds) RNAs leading to target-specific inhibition of gene expression by promoting mRNA degradation or translational repression. There are two RNAi pathways that…
Article 4: Optimisation of the PCR step of a qPCR assay
30 July 2009 | By
The deceptive simplicity of a typical qPCR assay is an important reason for the exponential growth in the adoption of qPCR-related technologies for both research and diagnostic applications. The only requirements for obtaining ostensibly quantitative data are a mixing of primers, DNA and a mastermix, their distribution into individual tubes…
New DNA sequencing technologies: applications, promises and challenges for pharmacogenomics
30 July 2009 | By
We are currently on the cusp of a technology-driven revolution in the field of genomics. The rapid evolution of DNA sequencing technology is already providing researchers with the ability to generate data about genetic variation and patterns of gene expression on an unprecedented scale; within just a few years it…
High throughput and high content screening microscopy: A microscopy based guideline
30 July 2009 | By
The understanding of properties of any biological system requires a detailed and quantitative analysis of its parts and their interactions. As different processes within a system occur at defined space and time, each process holds its own optimal observation and investigation technique. One of the most powerful tools to analyse…
Cellular Imaging & Analysis Business Unit
30 July 2009 | By
Mark Collins from Thermo Fisher Scientific, who provide analytical instruments, laboratory equipment, software, services, consumables and reagents, talks to us about current developments and future changes.
Drug Discovery 2009 – In association with SBS and BPS
30 July 2009 | By
Going from strength to strength ELRIG are pleased to announce the 3rd Drug Discovery Symposium. This year ELRIG will be joined by the BPS (British Pharmacological Society) for the event.
Real-time environmental monitoring: PAT solutions using rapid microbiological methods
In these economic times the pharmaceutical industry has expressed a renewed interest to explore ways in which to enhance the efficiency and agility of existing and future manufacturing processes. This is also true for laboratory-based operations that support forward processing and product release decisions. One function that can greatly benefit…
Drug-drug interactions: tools for drug transporter protein studies
30 July 2009 | By
Drug transporters are membrane proteins involved in the uptake or efflux of drugs by several tissues such as the intestine, liver, kidney and brain. They can have a significant impact on the pharmacokinetics of endogenous and exogenous compounds. Also, co-administered drugs or nutrients can influence the transporter activity which may…
