This article discusses options for selection of reagents and the extent to which they influence synthesised mRNA functionality...
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The aim of Quality by Design (QbD) is to build quality into a product and process from the outset. The pharmaceutical and related industries utilise powder blending operations to make solid dose drugs, yet the phenomena of powder mixing is the least understood of all sciences.
Hollow Fibre Diafiltration is rapid alternative to traditional methods of nanoparticle purification like ultracentrifugation.
Application Note: The sterility of the ControLyo™ process: reducing freeze dried product batch time without compromise to system integrity
Controlled nucleation is the most significant new development in freeze drying in quite some time.
The Milliflex® Quantum system (Merck Millipore) is a rapid method for the quantitative detection of contaminants in filterable samples...
Raman spectroscopy offers a rapid, convenient method for positive identification of pharmaceutical products and their raw materials – on the manufacturing floor, in inventory, and at the shipping dock.
Scandinavian Micro Biodevices (SMB), in Denmark, develops, produces and markets ‘point-of-care’ diagnostic systems for the veterinary market. In order to maintain a very low level of humidity in the clean room, a desiccant dehumidifier is required.
Heated crystalline pharmaceutical compounds undergo morphological changes that can be observed under a microscope. With hot-stage microscopy changes in melting points and ranges or crystallisation can be visualised for research and QC purposes in order to influence drug stability or effectiveness...
Application note: In-line PAT solutions for understanding and controlling fluidised bed granulation (FBG) processes
Determining CPP’s in DoE using Eyecon particle characteriser and Multieye Multipoint NIR.
Application Note: Multiparameter profiling of a Structure Activity Relationship (SAR) library for immunological activity in human PBMCs
We describe a no-wash, high throughput screen that provides a multiparametric activity profile for a structure activity relationship (SAR) library derived from immunomodulatory compounds...
Measurement and validation of the European Pharmacopoeia (EP) Colour scale.
Application Note: Raman spectroscopy of pharmaceutical ingredients under humidity controlled atmosphere
Monitoring the stability of the API under high humidity is critical to verify that the polymorphic active form remains intact. Being very chemically selective to subtle changes such as polymorphic forms, Raman spectroscopy is used to monitor and understand the stability of ingredients...
The BIOSTAT® Rocking Motion (RM) bioreactor system ensures optimal process control and cell growth for all single-use cell culture applications.
MALDI-ToF mass spectrometry, a phenotypical RMM for microbial identification, is a unique, highly accurate alternative method that facilitates cost-effective, precise and rapid data acquisition.
Application note: Enhancing reaction understanding with online NMR reaction monitoring – application to chemical route development
11 January 2016 | By Anna L. Dunn, Analytical Research and Development, Pfizer, Department of Chemistry, University of Wisconsin / Anna Codina, Bruker UK Limited / David A. Foley and Mark T. Zell, Analytical Research and Development, Pfizer
In this work, we demonstrate the complementarity of NMR and infrared (IR) spectroscopy and show the use of NMR to improve the understanding and robustness of the synthesis of an active pharmaceutical ingredient (API) precursor...